This study assessed the serum and urine response during the initial 12 hours after the ingestion of a new calcium formulation found in Shaklee’s Osteomatrix™.  Changes in serum calcium were measured at nine time points (0 hr, 1 hr, 2 hr, 3 hr, 4 hr, 5 hr, 6 hr, 8 hr & 12 hr) during the initial 12 hours following ingestion of 2 tablets containing a total of 500 mg calcium.   At carefully timed intervals, within minutes of providing a baseline blood sample, 10 healthy volunteers ingested two supplement tablets with 125 mL of water.  Results from the serum calcium assays on samples collected during the 12 hours immediately following supplementation were compared to each other and to the baseline serum calcium levels. The net changes in serum calcium during the 12 hours immediately following supplementation are presented graphically in figure below:

These results indicate that the net increase in serum calcium levels of the volunteers increased during the initial 5 hours after supplementation and then slowly decreased through the 12-hour monitoring period.  A comparison of the net changes in serum calcium during the first 12 hours following supplementation (ANOVA) determined that significant differences in the net increase of serum calcium from baseline occurred from 2 to 12 post calcium ingestion (P<.05).  These data demonstrate that the calcium provided in Osteomatrix™ is well-absorbed during the initial 12 hours following ingestion.